Amarillo is easily accessible from California all the way to North Carolina, as Interstate 40 runs east and west. Interstate 27 is the thoroughfare to the north and south and with the vision of the Ports-To-Plains initiative, a direct route from Mexico to Canada will be built through Amarillo. Loop 335 encompasses the city and allows for hazardous cargo to go around the city rather than through it. Highway 287 is a well-traveled route to Dallas, Texas.
